TLX1 Antibody
| Code | Size | Price |
|---|
| PSI-7361-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7361-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TLX1 Antibody: TCL3, HOX11, TCL3, T-cell leukemia homeobox protein 1, Homeobox protein Hox-11
Application Note:
TLX1 antibody can be used for detection of TLX1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
TLX1 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.
Background References:
- Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.
- Dube ID, Kamel-Reid S, Yuan CC, et al. A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t (10;14). Blood 1991; 78:2996-3003.
- Hatano M, Roberts CW, Minden M, et al. Deregulation of a homeobox gene, Hox11, by the t (10;14) in T cell leukemia. Science 1991; 253:79-82.
- Roberts CW, Shutter JR, Korsmeyer SJ et al. Hox11 controls the genesis of the spleen. Nature 1994; 368:747-9.
Buffer:
TLX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TLX1 antibody was raised against a 16 amino acid peptide near the amino terminus of human TLX1.
The immunogen is located within the first 50 amino acids of TLX1.
The immunogen is located within the first 50 amino acids of TLX1.
NCBI Gene ID #:
3195
NCBI Official Name:
T-cell leukemia homeobox 1
NCBI Official Symbol:
TLX1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 36 kDa
Observed: 35 kDa
Observed: 35 kDa
Protein Accession #:
NP_005512
Protein GI Number:
5031757
Purification:
TLX1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
Multiple isoforms of TLX1 exist due to alternative splicing events. TLX1 antibody is predicted to not cross-react with other TLX proteins.
Swissprot #:
P31314
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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