TLX2 Antibody

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ProSci
Product Code: PSI-7373
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-7373-0.02mg0.02mg£150.00
Quantity:
PSI-7373-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of TLX2 in rat brain tissue lysate with TLX2 antibody at (A) 0.5 and (B) 1 μg/mL.
2 / 3
Immunohistochemistry of TLX2 in rat brain tissue with TLX2 antibody at 2.5 μg/ml.
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Immunofluorescence of TLX2 in rat brain tissue with TLX2 antibody at 20 μg/ml.
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Western blot analysis of TLX2 in rat brain tissue lysate with TLX2 antibody at (A) 0.5 and (B) 1 μg/mL.
Immunohistochemistry of TLX2 in rat brain tissue with TLX2 antibody at 2.5 μg/ml.
Immunofluorescence of TLX2 in rat brain tissue with TLX2 antibody at 20 μg/ml.

Documents

Further Information

Additional Names:
TLX2 Antibody: NCX, HOX11L1, NCX, T-cell leukemia homeobox protein 2, Homeobox protein Hox-11L1
Application Note:
TLX2 antibody can be used for detection of TLX2 by Western blot at 0.5 - 1 μg/mL.

Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
TLX2 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX2, also known as homeobox11-like 1 (HOX11L1), is a DNA-binding nuclear transcription factor that appears to be crucial for the development of the peripheral nervous system. TLX2 is a downstream target of regulation by both PHOX2A and PHOX2B proteins during intestinal neuronal differentiation. In humans, loss-of-function of TLX2 may play a role in tumorigenesis of gastrointestinal stromal tumors.
Background References:
  • Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.
  • Puliti A, Cinti R, Betsos N, et al. HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1>p12 and mouse chromosome 6C3-D1. Cytogenet. Cell Genet. 1999; 84:115-7.
  • Borghini S, Di Duca M, Santamaria G, et al. Transcriptional regulation of TLX2 and impaired intestinal innervation: possible role of the PHOX2A and PHOX2B genes. Eur. J. Human Genet. 2007; 15:848-55.
  • Borghini S, Bachetti T, Fava M, et al. The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural crest derived cells. Biochem. J. 2006; 395:355-61.
Buffer:
TLX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TLX2 antibody was raised against an 18 amino acid peptide near the amino terminus of human TLX2.

The immunogen is located within amino acids 20 - 70 of TLX2.
NCBI Gene ID #:
3196
NCBI Official Name:
T-cell leukemia homeobox 2
NCBI Official Symbol:
TLX2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 31 kDa

Observed: 30 kDa
Protein Accession #:
NP_057254
Protein GI Number:
7706621
Purification:
TLX2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
TLX2 antibody is predicted to not cross-react with other TLX proteins.
Swissprot #:
O43763
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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