KHDC1 Antibody
| Code | Size | Price |
|---|
| PSI-7423-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7423-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
KHDC1 Antibody: NDG1, C6orf148, bA257K9.4, KH homology domain-containing protein 1
Application Note:
KHDC1 antibody can be used for detection of KHDC1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
KHDC1 Antibody: KHDC1 family members are K-homology (KH) domain-containing RNA binding proteins that are involved in various aspects of RNA metabolism, ranging from transcription to RNA splicing, transportation, translation, and stability (1). KHDC1 is highly expressed in oocytes and interacts with cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a key translational regulator controlling the polyA length of mRNAs (2,3). KHDC1 functions as a global translational repressor and induces apoptosis through an ER-dependent signaling pathway and that the C-terminal putative trans-membrane motif (TMM) is critical for its activities (3,4).
Background References:
- Valverde R, Edwards L, and Regan L. Structure and function of KH domains. FEBS J. 2008; 275:2712?26.
- Pierre A, Gautier M, Callebaut I, et al. Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family. Genomics 2007; 90:583-94.Cai C, Liu J, Wang C, et al. KHDC1A, a novel translational repressor, induces endoplasmic reticulum-dependent apoptosis. DNA Cell Biol. 2012; 31:1447-57.
Buffer:
KHDC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
KHDC1 antibody was raised against a 15 amino acid peptide near the amino terminus of human KHDC1.
The immunogen is located within amino acids 30 - 80 of KHDC1.
The immunogen is located within amino acids 30 - 80 of KHDC1.
Molecular Weight Explanation:
Probable post-translational modification
NCBI Gene ID #:
80759
NCBI Official Name:
KH homology domain containing 1
NCBI Official Symbol:
KHDC1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 18 kDa
Observed: 26 kDa
Observed: 26 kDa
Protein Accession #:
NP_085045
Protein GI Number:
117956389
Purification:
KHDC1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
SPECIFICITY:
KHDC1 antibody is human, mouse and rat reactive. At least three isoforms of KHDC1 are known to exist; this antibody will only detect the longest isoform.
Swissprot #:
Q4VXA5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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