B2M Antibody
| Code | Size | Price |
|---|
| PSI-7439-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7439-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
B2M Antibody: Beta-2-microglobulin
Application Note:
B2M antibody can be used for detection of B2M by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
B2M Antibody: Beta2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system (1,2). B2M is involved in the presentation of peptide antigens to the immune system and plays a critically important role in immune system function (3). It is expressed on nearly all nucleated cells and contains one Ig-like C1-type (immunoglobulin-like) domain (2,3). Mutations in the Beta 2-microglobulin gene can enhance the progression of malignant melanoma and osteoarthropathy (4,5).
Background References:
- Krangel MS, Orr HT, and Strominger JL. Assembly and maturation of HLA-A and HLA-B antigens in vivo. Cell 1979; 18:979-91.
- Skjodt K, Welinder KG, Crone M, et al. Isolation and characterization of chicken and turkey beta 2-microglobulin. Mol. Immunol. 1986; 23:1301-9.
- Ohashi K. Pathogenesis of beta2-microglobulin amyloidosis. Pathol. Int. 2001; 51:1-10.
- Blum C, Graham A, Yousefzadeh M, et al. The expression ratio of Map7/B2M is prognostic for survival in patients with stage II colon cancer. Int. J. Oncol. 2008; 33:579-84.
Buffer:
B2M Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (83%), Rat: (83%)
Immunogen:
B2M antibody was raised against a 15 amino acid peptide near the carboxy terminus of human B2M.
The immunogen is located within the last 50 amino acids of B2M.
The immunogen is located within the last 50 amino acids of B2M.
NCBI Gene ID #:
567
NCBI Official Name:
beta-2-microglobulin
NCBI Official Symbol:
B2M
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 13 kDa
Observed: 12 kDa
Observed: 12 kDa
Protein Accession #:
NP_004039
Protein GI Number:
4757826
Purification:
B2M Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
B2M antibody is human reactive.
Swissprot #:
P61769
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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