TFPI Antibody
| Code | Size | Price |
|---|
| PSI-7441-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7441-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TFPI Antibody: EPI, TFI, LACI, TFPI1, Tissue factor pathway inhibitor, Extrinsic pathway inhibitor, TFPI
Application Note:
TFPI antibody can be used for detection of TFPI by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
TFPI Antibody: Tissue factor pathway inhibitor (TFPI), also known as lipoprotein-associated coagulation inhibitor, is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation (1). TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop (1).
Background References:
- Broze GJ Jr and Girard TJ. Tissue factor pathway inhibitor: structure-function. Front. Biosci. 17:262-80.
Buffer:
TFPI Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rabbit: (92%)
Immunogen:
TFPI antibody was raised against a 13 amino acid peptide near the amino terminus of human TFPI.
The immunogen is located within amino acids 70 - 120 of TFPI.
The immunogen is located within amino acids 70 - 120 of TFPI.
NCBI Gene ID #:
7035
NCBI Official Name:
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
NCBI Official Symbol:
TFPI
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 33 kDa
Observed: 30 kDa
Observed: 30 kDa
Protein Accession #:
NP_006278
Protein GI Number:
5454114
Purification:
TFPI Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
TFPI antibody is human, mouse and rat reactive. At least two isoforms of TFPI are known to exist; this antibody will detect both isoforms.
Swissprot #:
P10646
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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