MUC1 Antibody
| Code | Size | Price |
|---|
| PSI-7451-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7451-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
MUC1 Antibody : EMA, MCD, PEM, PUM, KL-6, MAM6, MCKD, PEMT, CD227, H23AG, MCKD1, MUC-1, ADMCKD, ADMCKD1, CA 15-3, MUC-1/X, MUC1/ZD, MUC-1/SEC, Mucin-1, Breast carcinoma-associated antigen DF3
Application Note:
MUC1 antibody can be used for detection of MUC1 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
Mucin 1 (MUC1) is membrane-bound protein member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and also play a role in intracellular signaling (1). MUC1 is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC1 is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas (1).
Background References:
- Singh R and Bandyopadhyay D. MUC1: a target molecule for cancer therapy. Cancer Biol. Ther. 2007; 6:481-6.
Buffer:
MUC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (83%)
Immunogen:
MUC1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human MUC1.
The immunogen is located within the last 50 amino acids of MUC1 .
The immunogen is located within the last 50 amino acids of MUC1 .
NCBI Gene ID #:
4582
NCBI Official Name:
mucin 1, cell surface associated
NCBI Official Symbol:
MUC1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 53 (+ multiple others) kDa
Observed:42, 120 kDa
Observed:42, 120 kDa
Protein Accession #:
NP_001191215
Protein GI Number:
324120958
Purification:
MUC1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
MUC1 antibody is human and mouse reactive. Multiple isoforms of MUC1 are known to exist. MUC1 often migrates at a higher molecular weight in SDS-PAGE due to high levels of post-translational modification.
Swissprot #:
P15941
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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