ERAP2 Antibody
| Code | Size | Price |
|---|
| PSI-7469-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7469-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ERAP2 Antibody : LRAP, L-RAP, LRAP, Endoplasmic reticulum aminopeptidase 2, Leukocyte-derived arginine aminopeptidase
Application Note:
ERAP2 antibody can be used for detection of ERAP2 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
The endoplasmic reticulum (ER) aminopeptidase 2 (ERAP2), a member of the peptidase M1 family, like the related protein ERAP1, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2). Like ERAP1, ERAP2 is localized to the lumen of the ER and is thought to associate with ERAP1 as a heterodimer (1). Both ERAP1 and ERAP2 have been linked to several human diseases ranging from infections to autoimmunity and cancer, and may play a role in the innate immune response (reviewed in 3).
Background References:
- Saveanu L, Carroll O, Lindo V, et al. Concerted peptide trimming by EARP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat. Immunol. 2005; 6:689-97.
- Saric T, Chang SC, Hattori A, et al. An IFN-gamma induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat. Immunol. 2002; 3:1169-76.
- Cifaldi L, Romania P, Lorenzi S, et al. Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer. Int. J. Mol. Sci. 2012; 13:8338-52
Buffer:
ERAP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (75%)
Immunogen:
ERAP2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ERAP2.
The immunogen is located within amino acids 110 - 160 of ERAP2 .
The immunogen is located within amino acids 110 - 160 of ERAP2 .
NCBI Gene ID #:
64167
NCBI Official Name:
endoplasmic reticulum aminopeptidase 2
NCBI Official Symbol:
ERAP2
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 106 kDa
Observed: 120kDa
Observed: 120kDa
Protein Accession #:
NP_071745
Protein GI Number:
11641261
Purification:
ERAP2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
SPECIFICITY:
ERAP2 antibody is human reactive. Multiple isoforms of ERAP2 are known to exist. ERAP2 antibody is predicted to not cross-react with ERAP1.
Swissprot #:
Q6P179
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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