BTLA Antibody
| Code | Size | Price |
|---|
| PSI-7473-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7473-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
BTLA Antibody : BTLA1, CD272, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein
Application Note:
BTLA antibody can be used for detection of BTLA by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain (1). Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells (1,2). Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis (3).
Background References:
- Carreno BM and Collins M. BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 2003; 24:524-7.
- Kobayashi Y, Iwata A, Suzuki K, et al. B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc. Natl. Acad. Sci. USA 2013; 110:5121-6.
- Lin SC, Kuo CC, and Chan CH. Association of a BTLA gene polymorphism with a risk of rheumatoid arthritis. J. Biomed. Sci. 2006; 13:853-60.
Buffer:
BTLA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
BTLA antibody was raised against a 17 amino acid peptide near the center of human BTLA.
The immunogen is located within amino acids 170 - 220 of BTLA .
The immunogen is located within amino acids 170 - 220 of BTLA .
NCBI Gene ID #:
151888
NCBI Official Name:
B and T lymphocyte associated
NCBI Official Symbol:
BTLA
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 32 kDa
Observed: 40kDa
Observed: 40kDa
Protein Accession #:
NP_861445
Protein GI Number:
145580621
Purification:
BTLA Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
SPECIFICITY:
BTLA antibody is human specific. At least two isoforms of BTLA are known to exist.
Swissprot #:
Q7Z6A9
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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