CD160 Antibody
| Code | Size | Price |
|---|
| PSI-7475-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7475-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CD160 Antibody : NK1, BY55, NK28, CD160 antigen, Natural killer cell receptor BY55
Application Note:
CD160 antibody can be used for detection of CD160 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CD160, also known as BY55, is a lipid-anchored cell membrane glycoprotein that contains one immunoglobulin-like domain (1). It is expressed in small intestine, spleen and functional NK and T cytotoxic lymphocytes (1,2). CD160 exists as a disulfide-linked homomultimer that functions as a receptor for MHC (major histocompatability complex) molecules and is thought to regulate the function of NK cells (2,3). Additionally, CD160 interacts with TNFRSF14 and, via this interaction, is able to negatively regulate CD4+ T cell activation, indicating a role in immune system regulation (4).
Background References:
- Anumanthan A, Bensussan A, Boumsell L, et al. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J. Immunol. 1998; 161:2780-90.
- Agrawal S, Marquet J, Freeman GJ, et al. Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. J. Immunol. 1999; 162:1223-6.
- Le Bouteiller P, Tabiasco J, Polgar B, et al. CD160: a unique activating NK cell receptor. Immunol. Lett. 2011;138:93-6
- Chabot S, Jabrane-Ferrat N, Bigot K, et al. A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor. J. Exp. Med. 2011; 208:973-86.
Buffer:
CD160 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CD160 antibody was raised against a 17 amino acid peptide near the center of human CD160.
The immunogen is located within amino acids 50 - 100 of CD160 .
The immunogen is located within amino acids 50 - 100 of CD160 .
NCBI Gene ID #:
11126
NCBI Official Name:
CD160 molecule
NCBI Official Symbol:
CD160
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 20 kDa
Observed: 25kDa
Observed: 25kDa
Protein Accession #:
NP_008984
Protein GI Number:
5901910
Purification:
CD160 Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
CD160 antibody is human and mouse reactive. Multiple isoforms of CD160 are known to exist.
Swissprot #:
O95971
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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