PHF14 Antibody
| Code | Size | Price |
|---|
| PSI-7485-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7485-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
PHF14 Antibody : KIAA0783, PHD finger protein 14
Application Note:
PHF14 antibody can be used for detection of PHF14 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
PHF14, a novel plant homology domain (PHD) transcription factor, controls the proliferation of mesenchymal cells by regulating PDGFR alpha expression in embryonic development (1). PHD finger transcription factors are concerned with transcriptional regulation by interacting with modified histones (2), and dysregulation of several genes encoding PHD finger transcription factors, such as ING1 and RBP2, has been found in human cancer diseases suggesting these factors have an important role for cancer cell proliferation. PHF14 is a potential target for new treatments of lung fibrosis (1, 3).
Background References:
- Kitagawa M, Takebe A, Ono Y, et al. Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-a. J. Biol. Chem. 2012; 287:27983-96.
- Musco G and Peterson P. PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus. Epigenetics 2008; 3:310-4.
- Musselman CA and Kutateladze TG. PHD fingers: epigenetic effectors and potential drug targets. Mol. Interv. 2009; 9:314-23.
Buffer:
PHF14 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PHF14 antibody was raised against a 19 amino acid peptide near the amino terminus of human PHF14.
The immunogen is located within amino acids 210 - 260 of PHF14 .
The immunogen is located within amino acids 210 - 260 of PHF14 .
NCBI Gene ID #:
9678
NCBI Official Name:
PHD finger protein 14
NCBI Official Symbol:
PHF14
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 98 kDa
Observed: 100kDa
Observed: 100kDa
Protein Accession #:
NP_055475
Protein GI Number:
55769548
Purification:
PHF14 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
PHF14 antibody is human, mouse and rat reactive. Multiple isoforms of PHF14 are known to exist.
Swissprot #:
O94880
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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