LRRC26 Antibody
| Code | Size | Price |
|---|
| PSI-7539-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7539-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
LRRC26 Antibody: CAPC, bA350O14.10, CAPC, Leucine-rich repeat-containing protein 26, BK channel auxiliary gamma subunit LRRC26
Application Note:
LRRC26 antibody can be used for detection of LRRC26 by Western blot at 0.5 - 1 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
The LRRC26 protein was initially identified as a cytokeratin-associated protein whose expression was elevated in multiple cancer cell lines and cancer specimens as well in normal prostate and salivary gland tissues (1). LRRC26 was later found to negatively regulate the NF-kappaB activation and suppresses tumor growth and metastasis (2). LRRC26 can also act to selectively alter the efficacy of large conductance calcium-activated K (BK) channels (3).
Background References:
- Egland KA, Liu XF, Squires S, et al. High expression of a cytokeratin-associated protein in many cancers. Proc. Natl. Acad. Sci. USA 2006; 103:5929-34.
- Liu XF, Xiang L, Zhang Y, et al. CAPC negatively regulates NF-B activation and suppresses tumor growth and metastasis. Oncogene 2012; 31:1673-82.
- Almassy J and Begenisich T. The LRRC26 protein selectively alters the efficacy of BK channel activators. Mol. Pharmacol. 2012; 81:21-30.
Buffer:
LRRC26 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
LRRC26 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LRRC26.
The immunogen is located within the last 50 amino acids of LRRC26.
The immunogen is located within the last 50 amino acids of LRRC26.
NCBI Gene ID #:
389816
NCBI Official Name:
leucine rich repeat containing 26
NCBI Official Symbol:
LRRC26
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 37 kDa
Observed: 48 kDa
Observed: 48 kDa
Protein Accession #:
NP_001013675
Protein GI Number:
61966761
Purification:
LRRC26 antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
LRRC26 antibody is human specific.
Swissprot #:
Q2I0M4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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