ULK4 Antibody
| Code | Size | Price |
|---|
| PSI-7587-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7587-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ULK4 Antibody: FAM7C1, REC01035Unc-51-like kinase 4
Application Note:
ULK4 antibody can be used for detection of ULK4 by Western blot at 0.5 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
ULK4 belongs to the Ser/Thr protein kinase superfamily and plays a role in the ATP-dependent phosphorylation of target proteins (1). Knockout of ULK genes results in a severe defect in the autophagy pathway (2). ULK4, like the other Unc-51-like kinases such as ULK1, ULK2 and ULK3, is highly conserved among eukaryotes (3). ULK4 has been implicated as a gene involved in the development of hydrocephalus (3). This neurologic disorder is being used in animal models to elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans (4).
Background References:
- Suzuki K, Kubota Y, Sekito T, et al. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes to Cells 2007; 12:209?18.
- Lee EJ and Tournier C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 2011; 7:689-95.
- Zhou X, Babu JR, da Silva S, et al. Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Proc. Natl. Acad. Sci. USA 2007; 104:5842-7.
- Vogel P, Read RW, Hansen GM, et al. Congenital hydrocephalus in genetically engineered mice. Vet. Pathol. 2012; 49:166-81.
Buffer:
ULK4 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ULK4 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human ULK4.
The immunogen is located within amino acids 1120 - 1170 of ULK4.
The immunogen is located within amino acids 1120 - 1170 of ULK4.
NCBI Gene ID #:
54986
NCBI Official Name:
unc-51 like kinase 4
NCBI Official Symbol:
ULK4
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 140 kDa
Observed: 165 kDa
Observed: 165 kDa
Protein Accession #:
NP_060356
Protein GI Number:
151301204
Purification:
ULK4 antibody is affinity chromatography purified via peptide column.
Research Area:
Autophagy
SPECIFICITY:
ULK4 antibody is human and mouse reactive. Multiple isoforms of ULK4 are known to exist.
Swissprot #:
Q96C45
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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