THAP11 Antibody
| Code | Size | Price |
|---|
| PSI-7613-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7613-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
THAP11 Antibody: RONIN, CTG-B43a, CTG-B45d, HRIHFB2206, THAP domain-containing protein 11
Application Note:
THAP11 antibody can be used for detection of THAP11 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
The THAP domain-contining protein 11 (THAP11), also known as Ronin, is an essential factor involved in embryonic stem (ES) cell pluripotency and cell growth (1). THAP 11 contains a THAP domain, a conserved DNA-binding domain common to many proteins associated with chromatin modification and gene expression silencing, and has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases (2). THAP11 can also negatively regulate CD44 v6 expression through its interaction with the poly(rC) binding protein PCBP1 (3).
Background References:
- Dejosez M, Krumenacker JS, Zitur LJ, et al. Ronin is essential for embryogenesis and the pluripotency of mouse ES cells. Cell 2008; 133:1162-74.
- Roussigne M, Kossida S, Lavigne AC, et al. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 2003; 28:66-9.
- Lian WX, Yin RH, Kong XZ, et al. THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line. FEBS Lett. 2012; 586:1431-8.
Buffer:
THAP11 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
THAP11 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human THAP11.
The immunogen is located within the last 50 amino acids of THAP11.
The immunogen is located within the last 50 amino acids of THAP11.
NCBI Gene ID #:
57215
NCBI Official Name:
THAP domain containing 11
NCBI Official Symbol:
THAP11
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 35 kDa
Observed: 38 kDa
Observed: 38 kDa
Protein Accession #:
NP_065190
Protein GI Number:
40354197
Purification:
THAP11 antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
THAP11 antibody is human, mouse and rat reactive.
Swissprot #:
Q96EK4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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