TMIGD1 Antibody
| Code | Size | Price |
|---|
| PSI-7615-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7615-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TMIGD1 Antibody: TMIGD, UNQ9372, TMIGD, UNQ9372/PRO34164, Transmembrane and immunoglobulin domain-containing protein 1
Application Note:
TMIGD1 antibody can be used for detection of TMIGD1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
TMIGD1 (transmembrane and immunoglobulin domain containing 1) is a 262 amino acid single-pass membrane protein that contains two Ig-like C2-type (immunoglobulin-like) domains (1,2). It is a nonsecreted, glycosylated protein located in the cytoplasm and cell membrane (1). TMIGD1 might be a possible cell-differentiation marker in the intestine, whose expression is lost during cellular transformation and promote progression of tumorigenesis in the intestinal epithelium (2-4). TMIGD1 has also been postulated to play a role in cell adhesion (2).
Background References:
- Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003; 13:2265-70.
- Fujimoto K, Beauchamp RD, Whitehead RH. Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression. Gastroenterology 2002; 123:1941?8.
- Yan J, Jiang J, Lim CA, et al. Blimp-1 regulates cell growth through repression of p53 transcription. Proc. Natl. Acad. Sci. USA 2007; 104:1841-6.
- Cattaneo E, Laczko E, Buffoli F, et al. Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid). EMBO Mol Med. 2011; 3:334-47.
Buffer:
TMIGD1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (72%)
Immunogen:
TMIGD1 antibody was raised against an 18 amino acid peptide near the center of human TMIGD1.
The immunogen is located within amino acids 150 - 200 of TMIGD1.
The immunogen is located within amino acids 150 - 200 of TMIGD1.
NCBI Gene ID #:
388364
NCBI Official Name:
transmembrane and immunoglobulin domain containing 1
NCBI Official Symbol:
TMIGD1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 29 kDa
Observed: 24 kDa
Observed: 24 kDa
Protein Accession #:
NP_996663
Protein GI Number:
45592949
Purification:
TMIGD1 antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
TMIGD1 antibody is human, mouse and rat reactive. At least two isoforms of TMIGD1 are known to exist; this antibody will detect both isoforms.
Swissprot #:
Q6UXZ0
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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