Betatrophin Antibody
| Code | Size | Price |
|---|
| PSI-7619-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7619-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
Betatrophin Antibody: RIFL, TD26, ANGPTL8, PRO1185, PVPA599, Angptl8, UNQ599/PRO1185, Betatrophin, Angiopoietin-like protein 8
Application Note:
Betatrophin antibody can be used for detection of Betatrophin by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse and rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse and rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
The Betatrophin protein, also known as the hepatocellular carcinoma-associated protein TD26, is an adipocyte- and liver-enriched insulin targeted gene that is thought to play a role in lipid metabolism be regulating serum triglyceride levels (1,2). Betatrophin is closely related to the angiopoietin-like (ANGPTL) protein family. Betatrophin mRNA increases in the cold environment and after treatment with a high-fat diet, while its mRNA levels decrease in response to fasting, suggesting that it may play a role in mediating thermogenesis and energy homeostasis (3).
Background References:
- Ren G, Kim JY, and Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am. J. Endocrinol. Metab. 2012; 303:E334-51.
- Zhang R. Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem. Biophys. Res. Commun. 2012; 424:786-92.
- Fu Z, Yao F, Abou-Samra AB, et al. Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem. Biophys. Res. Commun. 2013; 430:1126-31.
Buffer:
Betatrophin antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Betatrophin antibody was raised against a 16 amino acid peptide near the amino terminus of human Betatrophin.
The immunogen is located within amino acids 40 - 90 of Betatrophin.
The immunogen is located within amino acids 40 - 90 of Betatrophin.
NCBI Gene ID #:
55908
NCBI Official Name:
chromosome 19 open reading frame 80
NCBI Official Symbol:
C19orf80
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 22 kDa
Observed: 22 kDa
Observed: 22 kDa
Protein Accession #:
NP_061157
Protein GI Number:
291219911
Purification:
Betatrophin antibody is affinity chromatography purified via peptide column.
Research Area:
Obesity
SPECIFICITY:
Betatrophin antibody is human, mouse and rat reactive. At least three isoforms of Betatrophin are known to exist; this antibody will detect the two largest isoforms.
Swissprot #:
Q6UXH0
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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