CCR7 Antibody
| Code | Size | Price |
|---|
| PSI-7649-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7649-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CCR7 Antibody: BLR2, EBI1, CD197, CDw197, CMKBR7, EVI1, C-C chemokine receptor type 7, BLR2, C-C CKR-7
Application Note:
CCR7 antibody can be used for detection of CCR7 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
The CCR7 protein is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation (1,2). The chemokine (C-C motif) ligand 19 (CCL19) has been reported to be a specific ligand of this receptor (3).
Background References:
- Birkenbach M, Josefsen K, Yalamanchil R, et al. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 1993; 67:2209-20.
- Forster R, Davalos-Misslitz AC, and Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 2008; 8:362-71.
- Yoshida R, Imai T, Hieshima K, et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 1997; 272:13803-9.
Buffer:
CCR7 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CCR7 antibody was raised against a 15 amino acid peptide near the center of human CCR7.
The immunogen is located within amino acids 180 - 230 of CCR7.
The immunogen is located within amino acids 180 - 230 of CCR7.
NCBI Gene ID #:
1236
NCBI Official Name:
chemokine (C-C motif) receptor 7
NCBI Official Symbol:
CCR7
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 42 kDa
Observed: 42 kDa
Observed: 42 kDa
Protein Accession #:
NP_001829
Protein GI Number:
4502641
Purification:
CCR7 antibody is affinity chromatography purified via peptide column.
Research Area:
Chemokines & Cytokines
SPECIFICITY:
CCR7 antibody is human specific. CCR7 antibody is predicted to not cross-react with other CCR proteins.
Swissprot #:
P32248
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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