FMR1 Antibody
| Code | Size | Price |
|---|
| PSI-7707-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7707-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
FMR1 Antibody: Fragile X mental retardation protein 1, FMRP
Application Note:
FMR1 antibody can be used for detection of FMR1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1). FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2). A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1). Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3).
Background References:
- Jin P and Warren ST. Understanding the molecular basis of fragile X syndrome. Hum. Mol. Genet. 2000; 9:901-8.
- Corbin F, Bouillon M, Fortin A, et al. The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes. Hum. Mol. Genet. 1997; 1465-72.
- Lu C, Lin L, Tan H, et al. Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice. Hum. Mol. Genet. 2012; 5039-47.
Buffer:
FMR1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
FMR1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FMR1.
The immunogen is located within the last 50 amino acids of FMR1.
The immunogen is located within the last 50 amino acids of FMR1.
NCBI Gene ID #:
2332
NCBI Official Name:
fragile X mental retardation 1
NCBI Official Symbol:
FMR1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 70 kDa
Observed: 74 kDa
Observed: 74 kDa
Protein Accession #:
NP_002015
Protein GI Number:
4503765
Purification:
FMR1 antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.
Swissprot #:
Q06787
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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