LAMTOR3 Antibody
| Code | Size | Price |
|---|
| PSI-7713-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7713-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
LAMTOR3 Antibody: MP1, MAPBP, MAPKSP1, PRO0633, MAP2K1IP1, Ragulator3, PRO2783, Ragulator complex protein LAMTOR3, MEK-binding partner 1, Mp1
Application Note:
LAMTOR3 antibody can be used for detection of LAMTOR3 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
The late endosomal/lysosomal adaptor MAPK and MTOR activator 3 (LAMTOR3) protein belongs to the LAMTOR family of proteins, and together with LAMTOR2 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling (1,2). This complex is involved in the regulation of late endosomal traffic and cellular proliferation (3) and plays a role in cellular host defense against Salmonella infection (4).
Background References:
- Wunderlich W, Fialka I, Teis D, et al. A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold MP1 on a late endosomal/lysosomal compartment. J. Cell Biol. 2001; 152:765-76.
- Teis D, Wunderlich W, and Huber LA. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev. Cell 2002; 3:803-14.
- Teis D, Taub N, Kurzbauer R, et al. p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J. Cell Biol. 2006; 175:861-8.
- Taub N, Nairz M, Hilber D, et al. The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection. J. Cell Sci. 2012; 125:2698-708.
Buffer:
LAMTOR3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken: (100%), Bovine: (100%)
Immunogen:
LAMTOR3 antibody was raised against an 15 amino acid peptide near the center of human LAMTOR3.
The immunogen is located within amino acids 40 - 90 of LAMTOR3.
The immunogen is located within amino acids 40 - 90 of LAMTOR3.
NCBI Gene ID #:
8649
NCBI Official Name:
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
NCBI Official Symbol:
LAMTOR3
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 14 kDa
Observed: 13 kDa
Observed: 13 kDa
Protein Accession #:
NP_068805
Protein GI Number:
11496277
Purification:
LAMTOR3 antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
LAMTOR3 antibody is human, mouse and rat reactive. At least two isoforms of LAMTOR3 are known to exist; this antibody will detect both isoforms. LAMTOR3 antibody is predicted to not cross-react with other LAMTOR family proteins.
Swissprot #:
Q9UHA4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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