CFTR Antibody
| Code | Size | Price |
|---|
| PSI-7717-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7717-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CFTR Antibody: CF, MRP7, ABC35, ABCC7, CFTR/MRP, TNR-CFTR, dJ760C5.1, Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C member 7, CFTR
Application Note:
CFTR antibody can be used for detection of CFTR by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the ATP-binding cassette (ABC) transporter superfamily, and a member of the MRP subfamily that is involved in multi-drug resistance (1,2). CFTR functions as a chloride channel and controls the regulation of other transport pathways (3). Mutations in this gene are associated with the autosomal recessive disorder cystic fibrosis, the most common, fatal, inherited disease of caucasian populations (1).
Background References:
- Kerem B, Rommens JM, Buchanan JA, et al. Identification of the cystic fibrosis gene: genetic analysis. Science 1989; 245:1073-80.
- Harris A and Argent BE. The cystic fibrosis gene and its product CFTR. Semin. Cell Biol. 1993; 4:37-44.
- Schwiebert EM, Benos DJ, Egan ME, et al. CFTR is a conductance regulator as well as a chloride channel. Physiol. Rev. 1999; 79:S145-66.
Buffer:
CFTR Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Sheep: (100%), Rabbit: (100%), Bovine: (95%), Pig: (89%), Horse: (89%), Guinea pig: (89%)
Immunogen:
CFTR antibody was raised against an 18 amino acid peptide near the carboxy terminus of human CFTR.
The immunogen is located within amino acids 1290 - 1340 of CFTR.
The immunogen is located within amino acids 1290 - 1340 of CFTR.
NCBI Gene ID #:
1080
NCBI Official Name:
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NCBI Official Symbol:
CFTR
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 163 kDa
Observed: 160 kDa
Observed: 160 kDa
Protein Accession #:
NP_000483
Protein GI Number:
90421313
Purification:
CFTR antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
SPECIFICITY:
CFTR antibody is human, mouse and rat reactive.
Swissprot #:
P13569
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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