GDPD5 Antibody
| Code | Size | Price |
|---|
| PSI-7739-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7739-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
GDPD5 Antibody: GDE2, PP1665, GDE2, PP6037, PP9363, UNQ1850/PRO3580, Glycerophosphodiester phosphodiesterase domain-containing protein 5, Glycerophosphodiester phosphodiesterase 2
Application Note:
GDPD5 antibody can be used for detection of GDPD5 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
The glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) protein, also known as GDE2, is a seven transmembrane, widely expressed protein (1) that is necessary for spinal motor neuron differentiation and retinoid-induced neuronal outgrowth (2,3). Altered choline phospholipid metabolism is a hallmark of cancer, and the elevated expression of GDPD5 correlates with malignant choline phospholipid metabolite profiles in human breast cancer (4).
Background References:
- Nogusa Y, Fujioka Y, Komatsu R, et al. Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6. Gene 2004; 337:173-9.
- Rao M and Sockanathan S. Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Science 2005; 309:2212-5.
- Yanaka N, Nogusa Y, Fujioka Y, et al. Involvement of membrane protein GDE2 in retinoic acid-induced neurite formation in Neuro2A cells. FEBS Lett. 2007; 581:712-8.
- Cao MD, Dopkens M, Krishnamachary B, et al. Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. NMR Biomed. 2012; 25:1033-42.
Buffer:
GDPD5 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken: (94%)
Immunogen:
GDPD5 antibody was raised against an 18 amino acid peptide near the amino terminus of human GDPD5.
The immunogen is located within the first 50 amino acids of GDPD5.
The immunogen is located within the first 50 amino acids of GDPD5.
NCBI Gene ID #:
81544
NCBI Official Name:
glycerophosphodiester phosphodiesterase domain containing 5
NCBI Official Symbol:
GDPD5
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 40, 67 kDa
Observed: 52 kDa
Observed: 52 kDa
Protein Accession #:
NP_110419
Protein GI Number:
189571657
Purification:
GDPD5 antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
GDPD5 antibody is human, mouse and rat reactive. At least three isoforms of GDPD5 are known to exist.
Swissprot #:
Q8WTR4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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