UBIAD1 Antibody
| Code | Size | Price |
|---|
| PSI-7751-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-7751-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
UBIAD1 Antibody: SCCD, TERE1, UbiA prenyltransferase domain-containing protein 1, Transitional epithelial response protein 1
Application Note:
UBIAD1 antibody can be used for detection of UBIAD1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
The UbiA prenyltransferase domain containing 1 (UBIAD1) protein , also known as TERE1, was initially identified as a down-regulated gene in transitional cell carcinoma of the bladder (1). Recently it has been shown to bind the cholesterol carrier APOE and modulate cellular cholesterol levels (2). Mutations in the UBIAD1 gene can cause Schnyder crystalline corneal dystrophy, an autosomal dominant disease characterized by progressive opacification of the cornea resulting from the local accumulation of lipids (3).
Background References:
- McGarvey TW, Nguyen T, Tomaszewski JE, et al. Isolation and characterization of TERE1 gene, a gene down-regulated in transitional cell carcinoma of the bladder. Oncogene 2001; 20:1042-51.
- Fredericks WJ, McGarvey T, Wang H, et al. The bladder tumor suppressor protein TERE1 (UBIAD1) modulates cell cholesterol: implications for tumor progression. DNA Cell Biol. 2011; 30:851-64.
- Orr A, Dube MP, Marcadier J, et al. Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy. PLoS One 2007; 2:e685.
Buffer:
UBIAD1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken: (87%)
Immunogen:
UBIAD1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human UBIAD1.
The immunogen is located within amino acids 210 - 260 of UBIAD1.
The immunogen is located within amino acids 210 - 260 of UBIAD1.
NCBI Gene ID #:
29914
NCBI Official Name:
UbiA prenyltransferase domain containing 1
NCBI Official Symbol:
UBIAD1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 37 kDa
Observed: 45 kDa
Observed: 45 kDa
Protein Accession #:
NP_037451
Protein GI Number:
7019551
Purification:
UBIAD1 antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
UBIAD1 antibody is human, mouse and rat reactive.
Swissprot #:
Q9Y5Z9
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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