IFIT1 Antibody

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ProSci
Product Code: PSI-7757
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-7757-0.02mg0.02mg£150.00
Quantity:
PSI-7757-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)

Images

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Western blot analysis of IFIT1 in rat small intestine tissue lysate with IFIT1 antibody at 1 μg/ml.
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Immunohistochemistry of IFIT1 in human small intestine tissue with IFIT1 antibody at 5 μg/mL.
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Immunofluorescence of IFIT1 in human small intestine tissue with IFIT1 antibody at 20 μg/mL.
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Western blot analysis of IFIT1 in rat small intestine tissue lysate with IFIT1 antibody at 1 μg/ml.
Immunohistochemistry of IFIT1 in human small intestine tissue with IFIT1 antibody at 5 μg/mL.
Immunofluorescence of IFIT1 in human small intestine tissue with IFIT1 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
IFIT1 Antibody: C56, P56, G10P1, IFI56, ISG56, IFI-56, IFIT-1, IFNAI1, RNM561, IFI-56K, Interferon-induced protein with tetratricopeptide repeats 1, Interferon-induced 56 kDa protein
Application Note:
IFIT1 antibody can be used for detection of IFIT1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 5 μg/mL. For Immunoflorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
The interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides (1,2). These proteins have been suggested to induce anti-viral cellular activities in response to infection (2). Together with the interferon-induced transmembrane protein 1 (IFITM1), IFIT1 inhibits the replication of the Hepatitis C virus, suggesting that it may be useful in the development of therapeutic treatments (3).
Background References:
  • Wathelet M, Moutschen S, Defilippi P, et al. Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons. Eur. J. Biochem. 1986; 155:11-7.
  • Fensterl V and Sen GC. The ISG56/IFIT1 gene family. J. Interferon Cytokine Res. 2011; 31:71-8.
  • Raychoudhuri A, Shrivastava S, Steele R, et al. ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. J. Virol. 2011; 85:12881-9.
Buffer:
IFIT1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IFIT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IFIT1.

The immunogen is located within amino acids 290 - 340 of IFIT1.
NCBI Gene ID #:
3434
NCBI Official Name:
interferon-induced protein with tetratricopeptide repeats 1
NCBI Official Symbol:
IFIT1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 53 kDa

Observed: 53 kDa
Protein Accession #:
NP_001539
Protein GI Number:
116534937
Purification:
IFIT1 antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
SPECIFICITY:
IFIT1 antibody is human, mouse and rat reactive. At least three isoforms of IFIT1 are known to exist. This antibody is predicted to not cross-react with other members of the IFIT protein family.
Swissprot #:
P09914
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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