Colcemid
| Code | Size | Price |
|---|
| CDX-C0022-M025 | 25 mg | £280.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20 °C
Documents
Further Information
Alternate Names/Synonyms:
Demecolcine; N-Deacetyl-N-methylcolchicine
Appearance:
Light yellow powder.
CAS:
477-30-5
Class:
6.1
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS06
Handling Advice:
Protect from light and moisture.
Hazards:
H300
InChi:
InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3
InChiKey:
NNJPGOLRFBJNIW-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 477-30-5. Formula: C21H25NO5. MW: 371.43. Synthetic. Depolymerizes microtubules and blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
MDL:
MFCD00075459
Molecular Formula:
C21H25NO5
Molecular Weight:
371.43
Package Type:
Vial
PG:
III
Precautions:
P264, P301, P310
Product Description:
Depolymerizes microtubules and blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
Purity:
>98% (HPLC)
Signal Word:
Danger
SMILES:
CNC1CCC2=CC(OC)=C(OC)C(OC)=C2C2=CC=C(OC)C(=O)C=C12
Solubility Chemicals:
Soluble in chloroform.
Source / Host:
Synthetic.
Transportation:
Excepted Quantity
UN Nummer:
UN 2811
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) K. Ray et al.; Eur. J. Biochem. 142, 577 (1984)