6-(Dimethylamino)purine
| Code | Size | Price |
|---|
| CDX-D0318-G001 | 1 g | £132.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4 °C
Documents
Further Information
Appearance:
White solid.
CAS:
938-55-6
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
InChiKey:
BVIAOQMSVZHOJM-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 938-55-6. Formula: C7H9N5. MW: 163.18. Synthetic. A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).
MDL:
MFCD00005573
Molecular Formula:
C7H9N5
Molecular Weight:
163.18
Package Type:
Vial
Product Description:
A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).
Purity:
>97% (HPLC)
SMILES:
CN(C)C1=C2NC=NC2=NC=N1
Solubility Chemicals:
Soluble in DMF.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) H. Bredereck et al.; Berichte der Deutschen Chemischen Gesellschaft 73B, 1058-65 (1940) | (2) J. Vesely et al.; European Journal of Biochemistry 224(2), 771-86 (1994) | (3) P. Chesne et al.; Nature Biotechnology 20(4), 366-369 (2002)