Fluo-3 AM
| Code | Size | Price |
|---|
| CDX-F0033-M001 | 1 mg | £248.00 |
Quantity:
| CDX-F0033-M010 | 10 mg | £1,939.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
BI
Storage:
-20 °C
Documents
Further Information
Alternate Names/Synonyms:
Fluo-3 AM
Appearance:
Dark red powder.
CAS:
121714-22-5
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C51H50Cl2N2O23/c1-28-7-9-39(54(19-47(62)74-24-69-30(3)57)20-48(63)75-25-70-31(4)58)45(13-28)66-11-12-67-46-14-34(8-10-40(46)55(21-49(64)76-26-71-32(5)59)22-50(65)77-27-72-33(6)60)51-35-15-37(52)41(61)17-42(35)78-43-18-44(38(53)16-36(43)51)73-23-68-29(2)56/h7-10,13-18H,11-12,19-27H2,1-6H3
InChiKey:
PTPUOMXKXCCSEN-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 121714-22-5. Formula: C51H50Cl2N2O23. MW: 1129.85. Synthetic. Ca2+-indicator fluo-3 for use with visible-light excitation sources in flow cytometry and confocal laser-scanning microscopy. Since about 1996, fluo-3 has also been extensively used in cell-based high-throughput screening assays for drug discovery. Fluo-3 AM is essentially nonfluorescent until it is hydrolyzed intracellularly and/or in the presence of Ca2+. The green-fluorescent emission (~525 nm) of Ca2+-bound fluo-3 is conventionally detected using optical filter sets designed for fluorescein (FITC). As prepared by Minta, Kao and Tsien, fluo-3 was originally reported to undergo an ~40-fold increase in fluorescence upon binding Ca2+.
MDL:
MFCD00083336
Molecular Formula:
C51H50Cl2N2O23
Molecular Weight:
1129.85
Package Type:
Vial
Product Description:
Ca2+-indicator fluo-3 for use with visible-light excitation sources in flow cytometry and confocal laser-scanning microscopy. Since about 1996, fluo-3 has also been extensively used in cell-based high-throughput screening assays for drug discovery. Fluo-3 AM is essentially nonfluorescent until it is hydrolyzed intracellularly and/or in the presence of Ca2+. The green-fluorescent emission (~525 nm) of Ca2+-bound fluo-3 is conventionally detected using optical filter sets designed for fluorescein (FITC). As prepared by Minta, Kao and Tsien, fluo-3 was originally reported to undergo an ~40-fold increase in fluorescence upon binding Ca2+.
Purity:
>90% (TLC)
SMILES:
CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=CC=C(C=C1OCCOC1=C(C=CC(C)=C1)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)C1=C2C=C(Cl)C(=O)C=C2OC2=CC(OCOC(C)=O)=C(Cl)C=C12
Solubility Chemicals:
Soluble in DMSO.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) T. Toyofuku et al.; Geochem. Geophys. Geosyst. 9(5) | (2008) | (2) D.M. Plank et al.; Meth. Cell Sc. 25(3-4), 123 (2004) | (3) P. Vandenberghe et al.; J. Immun.Meth. 127, 197 (1990) | (4) J.P.Y. Kao et al.; J. Biol. Chem. 264, 8179 (1989)
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