GSH-Oet
| Code | Size | Price |
|---|
| CDX-G0006-M100 | 100 mg | £78.00 |
Quantity:
| CDX-G0006-M500 | 500 mg | £280.00 |
Quantity:
| CDX-G0006-G005 | 5 g | £2,025.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20 °C
Documents
Further Information
Alternate Names/Synonyms:
Glutathione reduced ethyl ester; N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine-3-ethyl ester
Appearance:
Solid.
CAS:
92614-59-0
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1
InChiKey:
JKRODHBGNBKZLE-YUMQZZPRSA-N
Long Description:
Chemical. CAS: 92614-59-0. Formula: C12H21N3O6S. MW: 335.38. Synthetic. GSH-OEt is cellpermeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. GSH-OEt is a protective agent against cellular damage, such as cataracts and mitochondrial degeneration. It undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Glutathione monoethyl ester may be used to supplement cellular pools of GSH in vitro and in vivo and can prevent ROS formation, neutralize toxic products and block apoptosis pathway. The effect of glutathione (GSH) and glutathione ethyl ester (GSH-OEt) supplementation on GSH homeostasis and exercise-induced oxidative stress was also examined. Glutathione ethyl ester protects against cisplatin-induced ototoxicity in the rat.
MDL:
MFCD00156117
Molecular Formula:
C12H21N3O6S
Molecular Weight:
335.38
Package Type:
Vial
Product Description:
GSH-OEt is cellpermeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. GSH-OEt is a protective agent against cellular damage, such as cataracts and mitochondrial degeneration. It undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Glutathione monoethyl ester may be used to supplement cellular pools of GSH in vitro and in vivo and can prevent ROS formation, neutralize toxic products and block apoptosis pathway. The effect of glutathione (GSH) and glutathione ethyl ester (GSH-OEt) supplementation on GSH homeostasis and exercise-induced oxidative stress was also examined. Glutathione ethyl ester protects against cisplatin-induced ototoxicity in the rat.
Purity:
>90% (HPLC)
SMILES:
CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
Solubility Chemicals:
Soluble in DMSO (20mg/ml) or water (>100mg/ml).
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) M. A. Retamal et al.; PNAS, 103(12), 4475 (2006) | (2) C. Leeuwenburgh et al.; J. Nutr. 128(12), 2420 (1998) | (3) K.Nishida et al.; Res. Commun. Chem. Pathol. Pharmacol. 82, 49 (1993)
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