Physil chloride

4-(N-Phthalimidyl)-benzenesulfonyl chloride

Solid.

114341-14-9

32160000

liquid

GHS07

Protect from light and moisture.

H315, H319, H335

InChI=1S/C14H10ClNO3S/c15-20(18,19)12-7-5-11(6-8-12)16-9-10-3-1-2-4-13(10)14(16)17/h1-8H,9H2

PKWBLDDSBFCSPX-UHFFFAOYSA-N

Chemical. CAS: 114341-14-9. Formula: C14H10ClNO3S. MW: 307.75. Synthetic. It is known that phenol and p-cresol are promoters of skin tumors and also urinary excretion of phenol and p-cresol is increased by exposure to benzene, which has hemopoietic toxicity, and toluene, respectively. Therefore, the determination of phenol and p-cresol is important in clinical chemistry and toxicology. Because phenol and p-cresol are present in urine as sulfate or glucuronide conjugates, they are hydrolyzed enzymatically or with acid, followed by distillation or extraction with organic solvent prior to measurement by GC or HPLC. However, these GC and HPLC methods require relatively large sample volumes (more than 1 ml) because of their insufficient sensitivities for measuring small amounts of phenol and p-cresol. The application of fluorescent labeling techniques to HPLC result in a sensitive and selective method. Phthalimidylbenzenesulfonyl chlorides habe also been successfully used for high sensitivity labelling of amino acids prior to HPLC.

MFCD00674897

C14H10ClNO3S

307.75

Vial

P261, P305, P351, P338

It is known that phenol and p-cresol are promoters of skin tumors and also urinary excretion of phenol and p-cresol is increased by exposure to benzene, which has hemopoietic toxicity, and toluene, respectively. Therefore, the determination of phenol and p-cresol is important in clinical chemistry and toxicology. Because phenol and p-cresol are present in urine as sulfate or glucuronide conjugates, they are hydrolyzed enzymatically or with acid, followed by distillation or extraction with organic solvent prior to measurement by GC or HPLC. However, these GC and HPLC methods require relatively large sample volumes (more than 1 ml) because of their insufficient sensitivities for measuring small amounts of phenol and p-cresol. The application of fluorescent labeling techniques to HPLC result in a sensitive and selective method. Phthalimidylbenzenesulfonyl chlorides habe also been successfully used for high sensitivity labelling of amino acids prior to HPLC.

>98% (HPLC)

Warning

ClS(=O)(=O)C1=CC=C(C=C1)N1CC2=CC=CC=C2C1=O

Soluble in acetone.

Synthetic.

Non-hazardous

Fluorescent Reagents

41105331

Stable for at least 2 years after receipt when stored at +4°C.