TFMU
| Code | Size | Price |
|---|
| CDX-T0003-G001 | 1 g | £96.00 |
Quantity:
| CDX-T0003-GG25 | 2.5 g | £181.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4 °C
Documents
Further Information
Alternate Names/Synonyms:
4-(Trifluoromethyl)umbelliferone
Appearance:
White to off-white crystalline powder.
CAS:
575-03-1
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS06
Handling Advice:
Protect from light and moisture.
Hazards:
H300, H315, H319, H335
InChi:
InChI=1S/C10H5F3O3/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4,14H
InChiKey:
CCKWMCUOHJAVOL-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 575-03-1. Formula: C10H5F3O3. MW: 230.14. Synthetic. This compound is widely used as a substrate for Cytochrome P450. It has also been used as a marker substrate for assessment of Drug-Drug interactions to multiple isoforms of UDP-glucuronosyltransferases. Suitable as pH-indicator. Trifluoromethylumbelliferone is a slightly longer wavelength analog of 4-methylcoumarin (4-MU) with a pKa that more closely matches physiological pH values.
MDL:
MFCD00037578
Molecular Formula:
C10H5F3O3
Molecular Weight:
230.14
Package Type:
Vial
PG:
III
Precautions:
P261, P264, P301, P310, P305, P351, P338
Product Description:
This compound is widely used as a substrate for Cytochrome P450. It has also been used as a marker substrate for assessment of Drug-Drug interactions to multiple isoforms of UDP-glucuronosyltransferases. Suitable as pH-indicator. Trifluoromethylumbelliferone is a slightly longer wavelength analog of 4-methylcoumarin (4-MU) with a pKa that more closely matches physiological pH values.
Purity:
>98% (NMR)
Signal word:
Danger
SMILES:
OC1=CC=C2C(OC(=O)C=C2C(F)(F)F)=C1
Solubility Chemicals:
Soluble in alcohols, DMSO or DMF.
Source / Host:
Synthetic.
Transportation:
Excepted Quantity
UN Nummer:
UN 2811
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
(1) P. Baranczewski; Assay and Drug Developm. Techn. 2(4), 345 (2004) | (2) A.B. Renwick; Xenobiotica 30(10), 955 (2000) | (3) G. Luyten et al.; J. Histochem. Cytochem. 33, 965 (1985)
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