Me7BIO
| Code | Size | Price |
|---|
| AG-MR-C0022-M005 | 5 mg | £105.00 |
Quantity:
| AG-MR-C0022-M025 | 25 mg | £345.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
1-Methyl-7-bromo-indirubin-3'-oxime
Appearance:
Dark red solid.
CAS:
916440-98-7
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.Protect from light and moisture.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C17H12BrN3O2/c1-21-16-10(6-4-7-11(16)18)13(17(21)22)15-14(20-23)9-5-2-3-8-12(9)19-15/h2-8,19,23H,1H3/b15-13-,20-14+
InChiKey:
KUNCCRCBMOXXLE-WAVHTBQISA-N
Long Description:
Chemical. CAS: 916440-98-7. Formula: C17H12BrN3O2. MW: 370.2. N-methylated inactive control compound for 7BIO (Prod. No. MR-C0020). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.
Molecular Formula:
C17H12BrN3O2
Molecular Weight:
370.2
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
N-methylated inactive control compound for 7BIO (Prod. No. MR-C0020). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.
Purity:
>95% (NMR)
Signal word:
Warning
SMILES:
CN1C(=O)C(=C2/NC3=CC=CC=C3/C/2=NO)C2=C1C(Br)=CC=C2
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the anti-proliferative effects of indirubins: M. Knockaert, et al.; Oncogene 23, 4400 (2004) | Indirubin, the red shade of indigo: L. Meijer, et al. (Editors): In ?Life in Progress?, Station Biologique, Roscoff, 297 pp. (2006) | 7-Bromoindirubin-3'-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006) | An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007) | Cutting edge: Necrosis activates the NLRP3 inflammasome: H. Li, et al.; J. Immunol. 183, 1528 (2009)
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