Boromycin
Product Code: AG-CN2-0166
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0166-C250 | 250 ug | £105.00 |
Quantity:
| AG-CN2-0166-M001 | 1 mg | £310.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
Antibiotic A 28829; Ivomycin; NSC216128
Appearance:
Off-white solid.
CAS:
34524-20-4
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.
Hazards:
H302
InChi:
InChI=1S/C45H73BNO15/c1-24(2)36(47)39(50)54-27(5)30-16-12-11-13-17-32(48)42(7,8)34-21-19-26(4)45(57-34)38-41(52)56-31-23-29(53-28(31)6)15-14-18-33(49)43(9,10)35-22-20-25(3)44(58-35)37(40(51)55-30)59-46(60-38,61-44)62-45/h11-12,24-38,48-49H,13-23,47H2,1-10H3/q-1/p+1/b12-11+/t25-,26-,27-,28-,29-,30+,31+,32+,33-,34+,35+,36-,37+,38+,44+,45+,46?/m1/s1
InChiKey:
OOBFYEMEQCZLJL-UWTAGDQBSA-O
Long Description:
Chemical. CAS: 34524-20-4. Formula: C45H74BNO15. MW: 879.9. Isolated from Streptomyces sp. Boron-containing macrolide antibiotic. Antibacterial. Antiprotozoal (Plasmodium, Babesia). Anti-HIV compound. Ca2+ homeostasis modulator. Potentiator of bleomycin-induced anti-tumor activity. Used as a chiral selector in capillary electrophoresis.
MDL:
MFCD01939471
Molecular Formula:
C45H74BNO15
Molecular Weight:
879.9
Package Type:
Vial
Precautions:
P264, P301, P312, P330
Product Description:
Boron-containing macrolide antibiotic [1]. Antibacterial [1]. Antiprotozoal (Plasmodium, Babesia) [2]. Anti-HIV compound [3,6]. Ca2+ homeostasis modulator [4]. Potentiator of bleomycin-induced anti-tumor activity [5]. Used as a chiral selector in capillary electrophoresis [7].
Purity:
>99% (TLC)
Signal word:
Warning
SMILES:
[H][C@@]12O[B-]34O[C@@H](C(=O)O[C@@]([H])(CC=C/CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@H](C)[C@@]1(O3)O5)[C@@H](C)OC(=O)[C@H]([NH3+])C(C)C)[C@]1(O4)O[C@@]([H])(CC[C@H]1C)C(C)(C)[C@H](O)CCC[C@@H]1C[C@H](OC2=O)[C@@H](C)O1
Solubility Chemicals:
Soluble in DMSO, ethanol or methanol.
Source / Host:
Isolated from Streptomyces sp.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
References
Structure of boromycin: J.D. Dunitz, et al.; Helv. Chim. Acta 54, 1709 (1971) | Antibiotic A 28829: V. Prelog, et al.; US Patent 3,769,418 (1973) | Boromycin, an anti-HIV antibiotic: J. Kohno, et al.; Biosci. Biotechnol. Biochem. 60, 1036 (1996) | The effect of boromycin on the Ca2+ homeostasis: B. Lakatos, et al.; Mol. Cell Biochem. 231, 15 (2002) | Boromycin abrogates bleomycin-induced G2 checkpoint: M. Arai, et al.; J. Antibiot. 57, 662 (2004) | Biologically active compounds of semi-metals: T. Rezanka & K. Sigler; Phytochem. 69, 585 (2008) (Review) | Study on the use of boromycin as a chiral selector in capillary electrophoresis: V. Maier, et al.; J. Chromatogr. A. 1237, 128 (2012)
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