Quercetin . dihydrate
Product Code: AG-CN2-0409
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0409-G001 | 1 g | £30.00 |
Quantity:
| AG-CN2-0409-G005 | 5 g | £60.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Further Information
Alternate Names/Synonyms:
Sophoretin; Meletin; Xanthaurine; Quercetol; Quercitin; Quertine; Flavin meletin; NCI-C60106; NSC9219; NSC9221; CI 75670; CI Natural Yellow 10; BRN0317313
Appearance:
Pale yellow powder.
CAS:
6151-25-3
Class:
6.1
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS06
Handling Advice:
Protect from light.
Hazards:
H301
InChi:
InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
InChiKey:
REFJWTPEDVJJIY-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 6151-25-3. Formula: C15H10O7 . 2H20. MW: 302.2 . 36.0. Isolated from Umbelliferae sp. Multipotent flavonoid antioxidant. Potent free radical scavenger. Neuroprotective. Anticancer compound with chemosensitizing activity. Cell cycle arrest, apoptosis and autophagy inducer. Proteasome inhibitor. Pleiotropic kinase inhibitor, including tyrosine protein kinase (Trk), mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases, PI3-kinase activity, phospholipase A2 and protein kinase C (PKC). DNA topoisomerases inhibitor. SIRT1 activator. Heat shock proteins inhibitor. Reversible fatty acid synthase inhibitor. Antithrombotic, antihistaminic and anti-inflammatory agent. Monoamine oxidase inhibitor. Vasodilatory compound. anti-diabetic compound.
MDL:
MFCD00149487
Molecular Formula:
C15H10O7 . 2H20
Molecular Weight:
302.2 . 36.0
Package Type:
Vial
PG:
III
Precautions:
P264, P301, P310, P330
Product Description:
Multipotent flavonoid antioxidant. Potent free radical scavenger. Neuroprotective. Anticancer compound with chemosensitizing activity. Cell cycle arrest, apoptosis and autophagy inducer. Proteasome inhibitor. Pleiotropic kinase inhibitor, including tyrosine protein kinase (Trk), mitochondrial ATPase, cAMP- and cGMP-phosphodiesterases, PI3-kinase activity, phospholipase A2 and protein kinase C (PKC). DNA topoisomerases inhibitor. SIRT1 activator. Heat shock proteins inhibitor. Reversible fatty acid synthase inhibitor. Antithrombotic, antihistaminic and anti-inflammatory agent. Monoamine oxidase inhibitor. Vasodilatory compound. Anti-diabetic compound. Antiviral for the prevention and treatment of SARS-CoV-2 related disease (COVID-19)
Purity:
>95% (NMR)
Signal word:
Danger
SMILES:
OC1=CC(O)=C2C(OC(=C(O)C2=O)C2=CC=C(O)C(O)=C2)=C1
Solubility Chemicals:
Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water.
Source / Host:
Isolated from Umbelliferae sp.
Transportation:
Excepted Quantity
UN Nummer:
UN 2811
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
References
Pharmacological inhibitors of Fatty Acid Synthase (FASN) - catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? R. Lupu & J.A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006) (Review) | Health effects of quercetin: from antioxidant to nutraceutical: A.W. Boots, et al.; Eur. J. Pharmacol. 585, 325 (2008) (Review) | Multitargeted cancer prevention by quercetin: A. Murakami, et al.; Cancer Lett. 269, 315 (2008) (Review) | Inhibiting the transcription factor HSF1 as an anticancer strategy: L. Whitesell & S. Lindquist; Expert Opin. Ther. Targets 13, 469 (2009) (Review) | In vitro modulation of naturally occurring flavonoids on cytochrome P450 2A6 (CYP2A6) activity: K.H. Tiong, et al.; Xenobiotica 40, 458 (2010) (Review) | Regulation of SIRT1 in cellular functions: role of polyphenols: S. Chung, et al.; Arch. Biochem. Biophys. 501, 79 (2010) (Review) | Quercetin as a systemic chemopreventative agent: structural and functional mechanisms: E.E. Mendoza & R. Burd; Mini Rev. Med. Chem. 11, 1216 (2011) (Review) | Exploiting tyrosinase expression and activity in melanocytic tumors: quercetin and the central role of p53: A.J. Vargas, et al.; Integr. Cancer Ther. 10, 328 (2011) (Review) | Targeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization: M. Shen, et al.; Anticancer Agents Med. Chem. 12, 891 (2012) (Review) | Flavonoids acting on DNA topoisomerases: recent advances and future perspectives in cancer therapy: P. Russo, et al.; Curr. Med. Chem. 19, 5287 (2012) (Review) | Life or death: neuroprotective and anticancer effects of quercetin: F. Dajas; J. Ethnopharmacol. 143, 383 (2012) (Review) | Phytochemicals and their impact on adipose tissue inflammation and diabetes: A. Leiherer, et al.; Vascul. Pharmacol. 58, 3 (2013) (Review) | Autophagy, polyphenols and healthy ageing: K. Pallauf & G. Rimbach; Ageing Res. Rev. 12, 237 (2013) (Review) | Quercetin: a pleiotropic kinase inhibitor against cancer: G.L. Russo; Cancer Treat. Res. 159, 185 (2014) (Review) | Quercetin can reduce insulin resistance without decreasing adipose tissue and skeletal muscle fat accumulation: N. Arias, et al.; Genes Nutr. 9, 361 (2014) | Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19): R.M.L. Colunga Biancatelli, et al.; Front. Immunol. 11, 1451 (2020)(Review)
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