Papaverine . hydrochloride
Product Code: AG-CN2-0414
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0414-G001 | 1 g | £30.00 |
Quantity:
| AG-CN2-0414-G005 | 5 g | £65.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
6,7-Dimethoxy-1-veratrylisoquinoline; NSC 35443; NCI-C56359
Appearance:
White to off-white crystalline powder.
CAS:
61-25-6
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light.Protect from moisture.
Hazards:
H302
InChi:
InChI=1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H
InChiKey:
UOTMYNBWXDUBNX-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 61-25-6. Formula: C20H21NO4 . HCl. MW: 339.4 . 36.5. Synthetic. Originally isolated from Papaver somniferum. Smooth muscle relaxant and vasodilator. Phosphodiesterase PDE10A inhibitor. Antiviral. Antipsychotic. Potential inducer of browning in WAT.
MDL:
MFCD00012745
Molecular Formula:
C20H21NO4 . HCl
Molecular Weight:
339.4 . 36.5
Package Type:
Vial
Precautions:
P264, P301, P312, P330
Product Description:
Smooth muscle relaxant and vasodilator [4]. Phosphodiesterase PDE10A inhibitor [3,5,6]. Antiviral [1,2]. Antipsychotic [3]. Potential inducer of browning in WAT.
Purity:
>95% (NMR)
Signal word:
Warning
SMILES:
COC1=CC=C(CC2=NC=CC3=CC(OC)=C(OC)C=C23)C=C1OC
Solubility Chemicals:
Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water.
Source / Host:
Synthetic. Originally isolated from Papaver somniferum.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells: Y. Yoshikawa & K. Yamanouchi; J. Virol. 50, 489 (1984) | Papaverine hydrochloride: effects on HIV replication and T-lymphocyte cell function: M. Nokta, et al.; Immunopharmacol. 26, 181 (1993) | Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis: J.A. Siuciak, et al.; Neuropharmacol. 51, 386 (2006) | The effect of papaverine on ion channels in rat basilar smooth muscle cells: D.H. Han, et al.; Neurol. Res. 29, 544 (2007) | The PDE10A inhibitor, papaverine, differentially activates ERK in male and female rat striatal slices: Y.T. Hsu, et al.; Neuropharmacol. 61, 1275 (2011) | PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a huntington's disease mouse model: A. Giralt, et al.; Hippocampus 23, 684 (2013) | A novel thermoregulatory role for PDE10A in mouse and human adipocytes: M.K. Hankir, et al.; EMBO Mol. Med. 8, 796 (2016)
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