Peripherin Monoclonal Antibody
| Code | Size | Price |
|---|
| PSI-50-258-0.1mL | 0.1mL | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species: Mammal
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Peripherin antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Documents
Further Information
Background:
Peripherin is a ~57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.
Background References:
- Terao E, Janssens S, van den Bosch de Aquilar P, Portier M, Klosen P (2000) In vivo expression of the intermediate filament peripherin in rat motoneurons: modulation by inhibitory and stimulatory signals. Neuroscience 101(3):679-88.
- Roberson J, Doroudchi MM, Nguyen MD, Durham, HD, Shaw G, Julien JP, Mushynski WE. (2003) A neurotoxic peripherin splice variant in a mouse model of ALS. J. Cell Biol. 160(6):939-49.
- Boitard C, Villa MC, Becourt C, Gia HP, Huc C, Sempe P, Portier MM, Bach JF (1992) Peripherin: an islet antigen that is cross-reactive with nonobese diabetic mouse class II gene products. Proc Natl Acad Sci USA 89(1):172-6.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Recombinant rat peripherin expressed in and purified from E. coli.
NCBI Gene ID #:
24688
NCBI Official Name:
peripherin
NCBI Official Symbol:
Prph
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57
Protein Accession #:
P21807
Protein GI Number:
129822
Purification:
Total IgG fraction
Research Area:
Neuroscience
SPECIFICITY:
Specific for the ~57kDa peripherin protein. This antibody performs well on aldehyde fixed tissues.
Swissprot #:
P21807
User NOte:
Optimal dilutions for each application to be determined by the researcher.