SHP-2 Antibody

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ProSci
Product Code: PSI-79-236
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-236-0.1mg0.1mg£488.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from 293 cells untreated or treated with starvation using SHP-2 (Phospho-Tyr542).
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SHP-2 (Phospho-Tyr542).
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Western blot analysis of lysed extracts from 293 cells untreated or treated with starvation using SHP-2 (Phospho-Tyr542).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SHP-2 (Phospho-Tyr542).

Documents

Further Information

Additional Names:
CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, PTN11, PTP-2C, PTPN11
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
Background References:
  • Ferjoux G, et al. (2003) Mol Biol Cell. 2003; 14 (9): 3911-3928. Shi ZQ, et al. (2000) Mol Cell Biol. 20 (5): 1526-1536. Li C, Friedman JM. (1999) Proc Natl Acad Sci U S A ; 96 (17): 9677-9682Manes S, et al. (1999) Mol Cell Biol. 19 (4): 3125-3135. Oh ES, et al. (1999) Mol Cell Biol; 19 (4): 3205-3215.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SHP-2 (Phospho-Tyr542) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 542 (H-E-Y (p) -T-N) derived from Human SHP-2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
5781
NCBI Official Name:
protein tyrosine phosphatase, non-receptor type 11
NCBI Official Symbol:
PTPN11
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
72 kDa
Protein Accession #:
NP_002825.3
Protein GI Number:
33356177
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of SHP-2 only when phosphorylated at tyrosine 542.
Swissprot #:
Q06124