NDE1 Antibody
| Code | Size | Price |
|---|
| PSI-26-262-100ul | 100ul | £662.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store NDE1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Documents
Further Information
Additional Names:
NDE1, FLJ20101, HOM-TES-87, NUDE, NUDE1, NDE, LIS4
Application Note:
NDE1 antibody can be used for detection of NDE1 by ELISA at 1:62500. NDE1 antibody can be used for detection of NDE1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
NDE1 is required for centrosome duplication and formation and function of the mitotic spindle. It is essential for the development of the cerebral cortex. NDE1 may regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex
Background References:
- Burdick, K.E., (er) Hum. Mol. Genet. (2008) In press.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NDE1.
NCBI Gene ID #:
54820
NCBI Official Name:
nudE neurodevelopment protein 1
NCBI Official Symbol:
NDE1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
38 kDa
Protein Accession #:
NP_060138
Protein GI Number:
8923110
Purification:
Antibody is purified by peptide affinity chromatography method.
Research Area:
Neuroscience
Swissprot #:
Q9NXR1-2
User NOte:
Optimal dilutions for each application to be determined by the researcher.