Dopamine Decarboxylase Antibody

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ProSci
Product Code: PSI-XPS-2000
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-XPS-2000-0.1mL0.1mL£686.00
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Bovine (Cattle)
  • Rat
Application: Western Blot (WB)
Storage:
For long term storage ?80˚C is recommended, but shorter term storage at ?20˚C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.

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Dopamine Decarboxylase Antibody
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Dopamine Decarboxylase Antibody

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Further Information

Application Note:
Applications include Dot Blots (DB) and Western Blots (WB). Recognizes DDC in rat adrenal medulla and caudate. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
Background:
Aromatic L-amino acid decarboxylase (AADC; DOPA decarboxylase; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin. It is also involved in the biosynthesis of trace amines.
Background References:
  • Haycock, J.W., Becker, L., Ang, L., Furukawa, Y., Hornykiewicz, O., and Kish, S.J., "Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum," J. Neurochem. 87 (2003) 574 - 585.
  • Waymire, J.C. and Haycock, J.W. "Lack of regulation of aromatic L-amino acid decarboxylase in intact bovine chromaffin cells," J. Neurochem. 81 (2002) 589 - 593.
  • Berry, M.D., Juorio, A.V., Li, X.M., and Boulton, A.A. "Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme," Neurochem. Res. 21 (1996) 1075 -1087.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
DOPA Decarboxylase polyclonal antibody was raised against a SDS denatured, recombinant bovine aromatic DDC expressed in E. coli and purified from inclusion bodies.
NCBI Gene ID #:
280762
NCBI Official Name:
dopa decarboxylase (aromatic L-amino acid decarboxylase)
NCBI Official Symbol:
DDC
NCBI Organism:
Bos taurus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
55
Protein Accession #:
P27718
Protein GI Number:
125987819
Purification:
Affinity Purified
Research Area:
Neuroscience
SPECIFICITY:
Dopamine Decarboxylase antibody is specific immunolabeling of the ~55k DDC protein in Western blots of rat adrenal medulla.
Swissprot #:
P27718
User NOte:
Optimal dilutions for each application to be determined by the researcher.