Choline Acetyltransferase Antibody
| Code | Size | Price |
|---|
| PSI-50-265-0.1mL | 0.1mL | £669.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Caprine (Goat)
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Avian
- Cavia (Guinea pig)
- Human
- Mouse
- Rat
Applications:
- Immuno Electron Microscopy
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Choline Acetyltransferase antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Documents
Further Information
Background:
Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).
Background References:
- Karson CN, Casanova MF, Kleinman JE, Griffin WS (1993) Choline acetyltransferase in schizophrenia. Am. J.Psychiatry 150:454-459.
- Holt DJ, Herman MM, Hyde TM, Kleinman JE, Cinton CM, German DC, Hersh LB, Greybiel AM, Saper CB (1999) Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia. Neuroscience 94(1):21-31.
- Baskin DS, Browning JL, Pirozzolo FJ, Korporaal S, Baskin JA, Appel SH (1999) Brain choline acetyltransferase and mental function in Alzheimer disease. Arch Neurol. 56:1121-1123.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Native choline acetyltransferase purified from human placenta.
NCBI Gene ID #:
1103
NCBI Official Name:
choline O-acetyltransferase
NCBI Official Symbol:
CHAT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
70
Protein Accession #:
P28329
Protein GI Number:
281185509
Purification:
Affinity Purified
Research Area:
Neuroscience
SPECIFICITY:
Specific for the ~ 70k choline acetyltransferase protein
Swissprot #:
P28329
User NOte:
Optimal dilutions for each application to be determined by the researcher.