Synapsin Antibody
| Code | Size | Price |
|---|
| PSI-50-191-0.05mL | 0.05mL | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Storage:
Synapsin antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
Documents
Further Information
Background:
Synapsin I plays a key role in synaptic plasticity in the brain (Feng et al.,
2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate
the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of
synapsin I is a precise indicator of synapse formation (Moore and Bernstein, 1989; Stone et al.,
1994). Thus, Synapsin I immunocytochemistry provides a valuable tool for the study of
synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by
phosphorylation (Jovanovic et al., 2001; Kao et al., 2002).
Background References:
- Feng J, Chi P, Blanpied TA, Xu YM, Magarinos AM, Ferreira A, Takahashi RH, Kao HT, McEwen BS, Ryan TA, Augustine GJ, Greengard P (2002) Regulation of neurotransmitter release by synapsin III. J Neurosci 22:4372- 4380.
- Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC, Jr., Greengard P, Czernik AJ (2001) Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals. J Neurosci 21:7944-7953.
- Kao HT, Song HJ, Porton B, Ming GL, Hoh J, Abraham M, Czernik AJ, Pieribone VA, Poo MM, Greengard P (2002) A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth. Nature Neurosci 5:431- 437.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Native protein purified from bovine brain
NCBI Gene ID #:
281510
NCBI Official Name:
synapsin I
NCBI Official Symbol:
SYN1
NCBI Organism:
Bos taurus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
78
Protein Accession #:
P17599
Protein GI Number:
1351166
Purification:
Neat Serum
Research Area:
Neuroscience
Swissprot #:
P17599
User NOte:
Optimal dilutions for each application to be determined by the researcher.