GluR2 Antibody

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ProSci
Product Code: PSI-50-218
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-218-0.1mL0.1mL£686.00
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Avian
  • Fish
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
GluR2 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

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Western blot of a rat hippocampal (Hipp) lysate showing the specific immunolabeling of the ~100k GluR2 protein.
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Western blot of a rat hippocampal (Hipp) lysate showing the specific immunolabeling of the ~100k GluR2 protein.

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Further Information

Application Note:
The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will also react with chicken, human, mouse, non-human primates and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Background:
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Kein?nen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD (Chung et al., 2003)
Background References:
  • Chung HJ, Steinberg JP, Huganir RL, Linden DJ (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755.
  • Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
  • Kein?nen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA, Sakmann B, Seeburg PH (1990) A family of AMPA-selective glutamate receptors. Science 249:556-560.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from rat GluR2, conjugated to keyhole limpet hemocyanin (KLH).
NCBI Gene ID #:
29627
NCBI Official Name:
glutamate receptor, ionotropic, AMPA 2
NCBI Official Symbol:
Gria2
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
100
Protein Accession #:
P19491
Protein GI Number:
3287964
Purification:
Affinity Purified
Research Area:
Neuroscience
Swissprot #:
P19491
User NOte:
Optimal dilutions for each application to be determined by the researcher.