GluR2/3 Antibody

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ProSci
Product Code: PSI-50-219
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-219-0.1mL0.1mL£686.00
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Avian
  • Fish
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
GluR2/3 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

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Western blot of rat hippocampal lysate showing specific immunolabeling of the ~100k GluR2/3 protein.
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Western blot of rat hippocampal lysate showing specific immunolabeling of the ~100k GluR2/3 protein.

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Further Information

Application Note:
The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will also react with chicken, human, mouse and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Background:
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Kein?nen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003; Seidenman et al., 2003; Chung et al., 2003; Yan et al., 2002).
Background References:
  • Chung HJ, Steinberg JP, Huganir RL, Linden DJ (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755.
  • Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
  • Kein?nen K, Wisden W, Sommer B, Werner P, Herb A, Verdoorn TA, Sakmann B, Seeburg PH (1990) A family of AMPA-selective glutamate receptors. Science 249:556-560.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3
NCBI Gene ID #:
29627
NCBI Official Name:
glutamate receptor, ionotropic, AMPA 2
NCBI Official Symbol:
Gria2
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
100
Protein Accession #:
P19491
Protein GI Number:
3287964
Purification:
Affinity Purified
Research Area:
Neuroscience
Swissprot #:
P19491
User NOte:
Optimal dilutions for each application to be determined by the researcher.