Dynamin Antibody

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ProSci
Product Code: PSI-50-206
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-206-0.1mL0.1mL£686.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Avian
  • Bovine (Cattle)
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
Dynamin antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

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Western Blot of rat cortex lysate showing labeling of the ~95k Dynamin protein.
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Western Blot of rat cortex lysate showing labeling of the ~95k Dynamin protein.

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Further Information

Application Note:
The antibody has been demonstrated to work in rat. It is also anticipated that the antibody will work with human, mouse, non-human primates, cow and chicken based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Background:
Dynamin is a member of a group of nerve terminal proteins called dephosphins that regulate synaptic vesicle endocytosis (Cousin et al., 2001; Graham et al., 2002; Tsuboi et al., 2002). There are 3 known isofoms of Dynamin, each having several splice variants as well. Dynamin I is expressed only in neurons whereas Dynamin II is ubiquitously expressed and Dynamin III is found primarily in the testes. Dynamin 1 is phosphorylated by PKC and dephosphorylated by calcineurin.
Background References:
  • Cousin MA, Tan TC, Robinson PJ (2001) Protein phosphorylation is required for endocytosis in nerve terminals: potential role for the dephosphins dynamin I and synaptojanin, but not AP180 or amphiphysin. J Neurochem 76:105-116.
  • Graham ME, O'Callaghan DW, McMahon HT, Burgoyne RD (2002) Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size. Proc Natl Acad Sci USA 99:7124-7129.
  • Tan TC, Valova VA, Malladi CS, Graham ME, Berven LA, Jupp OJ, Hansra G, McClure SJ, Sarcevic B, Boadle RA, Larsen MR, Cousin MA, Robinson PJ (2003) cdk5 is essential for synaptic vesicle endocytosis. Nat Cell Biol 5:701-710.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the N-terminal region of human Dynamin, conjugated to keyhole limpet hemocyanin (KLH).
NCBI Gene ID #:
1759
NCBI Official Name:
dynamin 1
NCBI Official Symbol:
DNM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
95
Protein Accession #:
Q05193
Protein GI Number:
172046078
Purification:
Affinity Purified
Research Area:
Neuroscience
Swissprot #:
Q05193
User NOte:
Optimal dilutions for each application to be determined by the researcher.