Neurofilament NF-L Monoclonal Antibody

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ProSci
Product Code: PSI-50-255
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-255-0.1mL0.1mL£686.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species:
  • Bovine (Cattle)
  • Chicken (Gallus)
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Neurofilament NF-L antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

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Western blot of rat cortex lysate showing specific immunolableing of the ~ 68k NF-L protein.
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Western blot of rat cortex lysate showing specific immunolableing of the ~ 68k NF-L protein.

Documents

Further Information

Background:
Neurofilaments are the 10nm or intermediate filament proteins specifically in neurons, and are composed predominantly of three major proteins called NF- NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68 kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. Mutations in the protein region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease.
Background References:
  • Harris, J., Ayyub, C. and Shaw G. (1991) A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. J Neurosci Res 30:47-62.
  • Mersiyanova IV, Perepelov AV, Polyakov AV, Sitnikov VF, Dadali EL, Oparin RB, Petrin AN and Evgrafov OV. (2000) A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene. Am. J. Hum. Genet. 67:37-46.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Preparation of porcine intermediate filaments.
NCBI Gene ID #:
4747
NCBI Official Name:
neurofilament, light polypeptide
NCBI Official Symbol:
NEFL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
68
Protein Accession #:
P07196
Protein GI Number:
62511894
Purification:
Total IgG fraction
Research Area:
Neuroscience
SPECIFICITY:
Specific for the ~68k Neurofilament L protein.
Swissprot #:
P07196
User NOte:
Optimal dilutions for each application to be determined by the researcher.