Tyrosine Hydroxylase Antibody

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ProSci
Product Code: PSI-50-262
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-262-0.1mL0.1mL£686.00
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Mammal
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Tyrosine Hydroxylase antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

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Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k TH protein.
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Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k TH protein.

Documents

Further Information

Background:
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson?s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004).
Background References:
  • Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW (2004) Tyrosine hydroxylase phosphorylation: regulation and consequences. J Neurochem 91:1025-1043.
  • Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.
  • Salvatore MF, Waymire JC, Haycock JW (2001) Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ. J Neurochem 79:349-360.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma.
NCBI Gene ID #:
25085
NCBI Official Name:
tyrosine hydroxylase
NCBI Official Symbol:
Th
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60
Protein Accession #:
P04177
Protein GI Number:
136577
Purification:
Affinity Purified
Research Area:
Neuroscience
SPECIFICITY:
Specific for the ~60k tyrosine hydroxylase protein.
Swissprot #:
P04177
User NOte:
Optimal dilutions for each application to be determined by the researcher.