STAT3 Antibody

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ProSci
Product Code: PSI-79-122
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-122-0.1mg0.1mg£488.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from HeLa cells using STAT3 (Phospho-Tyr705).
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT3 (Phospho-Tyr705).
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Western blot analysis of lysed extracts from HeLa cells using STAT3 (Phospho-Tyr705).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT3 (Phospho-Tyr705).

Documents

Further Information

Additional Names:
APRF, HIES, STAT5, APRF, Acute-phase response factor
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
Background References:
  • Fan G, et al. (2003) J Biol Chem. 278 (52): 52432-52436. Barry FA, et al. (2003) FEBS Lett. 553 (1-2): 173-178. Welsh, et al. (1996) Trends Cell Biol. 6: 274-279. Srivastava A K, et al. (1998) Mol Cell Biochem. 182: 135-141.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
STAT3 (Phospho-Tyr705) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 705 (A-P-Y (p) -L-K) derived from Human STAT3.
Modifications:
Phospho-Specific
NCBI Gene ID #:
6774
NCBI Official Name:
signal transducer and activator of transcription 3 (acute-phase response factor)
NCBI Official Symbol:
STAT3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
88 kDa
Protein Accession #:
NP_003141.2
Protein GI Number:
21618338
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Apoptosis,Cancer
SPECIFICITY:
This antibody detects endogenous level of STAT1 only when phosphorylated at serine 727.
Swissprot #:
P40763