p70 S6 Kinase Antibody

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ProSci
Product Code: PSI-79-569
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-79-569-0.1mg0.1mg£481.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.

Images

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Western blot analysis of lysed extracts from 293 cells using p70 S6 Kinase (Ab-389).
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Immunofluorescence staining of methanol-fixed HeLa cells using p70 S6 Kinase(Ab-389).
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Western blot analysis of lysed extracts from 293 cells using p70 S6 Kinase (Ab-389).
Immunofluorescence staining of methanol-fixed HeLa cells using p70 S6 Kinase(Ab-389).

Documents

Further Information

Additional Names:
S6K, PS6K, S6K1, STK14A, p70-S6K, p70S6KA, p70-alpha, S6K-beta-1, p70(S6K)-alpha, KS6B1, P70-S6K, RPS6KB1, S6K
Application Note:
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Background:
Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.
Background References:
  • Satoru Eguchi et al. (1999) J Biol Chem, Vol. 274: 36843-36851Papst PJ, et al. (1998) J Biol Chem. 273 (24): 15077-84. Ulrike Krause et al. (2002) Eur. J. Biochem. 269: 3751-3759 cLe, X. F, et al. (2003) Oncogene 22: 484?97
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
p70 S6 Kinase (Ab-389) antibody was raised against a peptide sequence around aa.387~391 (G-F-T-Y-V) derived from Human p70 S6 Kinase.
NCBI Gene ID #:
6198
NCBI Official Name:
ribosomal protein S6 kinase, 70kDa, polypeptide 1
NCBI Official Symbol:
RPS6KB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
70, 85 kDa
Protein Accession #:
NP_003152.1
Protein GI Number:
4506737
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Apoptosis,Cancer
SPECIFICITY:
This antibody detects endogenous level of total p70 S6 Kinase protein.
Swissprot #:
P23443