PKM1/2 Antibody
| Code | Size | Price |
|---|
| PSI-79-662-0.1mg | 0.1mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
Documents
Further Information
Additional Names:
PK3, TCB, OIP3, PKM2, CTHBP, THBP1, HEL-S-30, C10orf66, HOYS6, PKM, PK3, PK2
Application Note:
Western Blot: 1:1000
Background:
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Background References:
- Christofk, H. R. et al. (2008) Nature 452, 230-3. Mazurek, S. et al. (2005) Semin Cancer Biol 15, 300-8. Dombrauckas, J. D. et al. (2005) Biochemistry 44, 9417-29. Hitosugi, T. et al. (2009) Sci Signal 2, ra73.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PKM1/2 antibody was raised against a peptide sequence around aa. 36~40 (D-S-P-P-I) derived from Human PKM1/2.
NCBI Gene ID #:
5315
NCBI Official Name:
pyruvate kinase, muscle
NCBI Official Symbol:
PKM
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
NP_872270.1
Protein GI Number:
33286420
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Stem Cell
SPECIFICITY:
This antibody detects endogenous levels of total PKM1/2 protein.
Swissprot #:
P14618