KCNN2 Antibody
| Code | Size | Price |
|---|
| PSI-28-239-100ul | 100ul | £609.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store KCNN2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Documents
Further Information
Additional Names:
KCNN2, SK2, hSK2, SKCA2, KCa2.2, SKCa 2
Application Note:
KCNN2 antibody can be used for detection of KCNN2 by ELISA at 1:62500. KCNN2 antibody can be used for detection of KCNN2 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN2 is a member of the KCNN family of potassium channel genes.
Background References:
- Feranchak, A.P., et al., (2004) Gastroenterology 127 (3), 903-913.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KCNN2.
NCBI Gene ID #:
3781
NCBI Official Name:
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
NCBI Official Symbol:
KCNN2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
64 kDa
Protein Accession #:
NP_067627
Protein GI Number:
25777645
Purification:
Antibody is purified by protein A chromatography method.
Research Area:
Membrane
Swissprot #:
Q9H2S1
User NOte:
Optimal dilutions for each application to be determined by the researcher.