CHRNB2 Antibody
| Code | Size | Price |
|---|
| PSI-28-226-100ul | 100ul | £609.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store CHRNB2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Documents
Further Information
Additional Names:
CHRNB2, EFNL3, nAChRB2
Application Note:
CHRNB2 antibody can be used for detection of CHRNB2 by ELISA at 1:312500. CHRNB2 antibody can be used for detection of CHRNB2 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.
Background References:
- Hales, T.G., (2006) J. Biol. Chem. 281 (12), 8062-8071.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CHRNB2.
NCBI Gene ID #:
1141
NCBI Official Name:
cholinergic receptor, nicotinic, beta 2 (neuronal)
NCBI Official Symbol:
CHRNB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
NP_000739
Protein GI Number:
4502833
Purification:
Antibody is purified by protein A chromatography method.
Research Area:
Membrane ,Signal Transduction
Swissprot #:
P17787
User NOte:
Optimal dilutions for each application to be determined by the researcher.