Potassium Channel Antibody
| Code | Size | Price |
|---|
| PSI-XPS-2027-0.1mL | 0.1mL | £686.00 |
Quantity:
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Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Amphibian
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Potassium Channel, Kv2.2 Subunit antibody can be stored at -20˚C. After reconstitution in 50 μl PBS, the antibody should be aliquot and stored at -20˚C and is stable at -20˚C for at least 1 year. Ambient shipment is suitable for both i
Documents
Further Information
Application Note:
Potassium Channel antibody can be used for specific immunolabeling of the ~125k Kv 2.2 protein in Western blots. Applications include Dot Blots (DB), Immunohistochemistry (IHC) and Western Blots (WB). Rabbit anti-Potassium Channel, Kv2.2 recognizes Kv2.2 in rat and Xenopus. When internally tested under ideal conditions the working dilutions were 1:1000 for IHC, DB and WB.
Background:
Voltage-gated K+ channels are important determinants of neuronal membrane excitability, and differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes. Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells.
Background References:
- Burger, C. and Ribera, A.B. "Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development," J Neurosci. 16 (1996) 1412 - 1421.
- Pongs, O. "Voltage-gated potassium channels: from hyperexcitability to excitement," FEBS Lett. 452 (1999) 31-35.
- Maletic-Savatic, M., Lenn, N.J., and Trimmer, J.S. "Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro," J Neurosci. 15 (1995) 3840-3851.
- Hwang, P.M., Fotuhi, M., Bredt, D.S., Cunningham, A.M., and Snyder, S.H. "Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily," J. Neurosci., 13 (1993) 1569 - 1576.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Potassium Channel, Kv2.
NCBI Gene ID #:
117105
NCBI Official Name:
potassium voltage gated channel, Shab-related subfamily, member 2
NCBI Official Symbol:
Kcnb2
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
100
Protein Accession #:
Q63099
Protein GI Number:
24418850
Purification:
Affinity Purified
Research Area:
Signal Transduction ,Neuroscience
Swissprot #:
Q63099
User NOte:
Optimal dilutions for each application to be determined by the researcher.