SNAP25 Antibody

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ProSci
Product Code: PSI-50-190
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-50-190-0.1mL0.1mL£686.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Avian
  • Bovine (Cattle)
  • Canine (dog)
  • Cavia (Guinea pig)
  • Fish
  • Human
  • Mouse
  • Rat
Application: Western Blot (WB)
Storage:
SNAP25 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Images

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Western blot of rat cortex lysate showing specific labeling of the ~25k SNAP25 protein.
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Western blot of rat cortex lysate showing specific labeling of the ~25k SNAP25 protein.

Documents

Further Information

Background:
SNAP25 (Synaptosomal associated protein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer?s Disease (Greber et al.,1999). In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia (Fatemi et al., 2001).
Background References:
  • Fatemi SH, Sidwell R, Kist D, Akhter P, Meltzer HY, Bailey K, Thuras P, Sedgwick J (1998) Differential expression of synaptosome-associated protein 25 kDa (Snap25) in hippocampi of neonatal mice following exposure to human influenza virus in utero. Brain Res 800(1):1-9..
  • Greber S, Cairns N, Lubec G, Fountoulakis M (1999) Decreased levels of the synaptosomal associated protein 25 in the brains of patients with Down Syndrome and Alzheimer?s Disease. Electrophoresis 20 (4-5):928-34.
  • Ando K, Kudo Y, Takahashi M (2005) Negative regulation of neurotransmitter release by calpain: a possible specific involvement of Snap25 cleavage. J Neurochem 94(3):651-8.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat SNAP25 conjugated to keyhole limpet hemocyanin (KLH).
NCBI Gene ID #:
25012
NCBI Official Name:
synaptosomal-associated protein 25
NCBI Official Symbol:
Snap25
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
25
Protein Accession #:
P60881
Protein GI Number:
46397720
Purification:
Affinity Purified
Swissprot #:
P60881
User NOte:
Optimal dilutions for each application to be determined by the researcher.